This is a list of films which placed number one at the weekend box office for the year 2012.
| # | Date | Film | Gross | Notes |
|---|---|---|---|---|
| 1 | January 8, 2012 | The Devil Inside | $13,421,815 | |
| 2 | January 15, 2012 | Contraband | $19,604,724 | |
| 3 | January 22, 2012 | Underworld: Awakening | $21,185,098 | |
| 4 | January 29, 2012 | Man on a Ledge | $19,783,211 | |
| 5 | February 5, 2012 | The Woman in Black | $18,442,105 | |
| 6 | February 12, 2012 | The Vow | $26,986,438 | |
| 7 | February 19, 2012 | Safe House | $20,494,217 | |
| 8 | February 26, 2012 | Ghost Rider: Spirit of Vengeance | $15,224,655 | |
| 9 | March 4, 2012 | The Lorax | $37,463,062 | |
| 10 | March 11, 2012 | The Lorax | $20,189,216 | |
| 11 | March 18, 2012 | 21 Jump Street | $22,170,847 | |
| 12 | March 25, 2012 | The Hunger Games | $68,673,044 | |
| 13 | April 1, 2012 | The Hunger Games | $30,256,194 | |
| 14 | April 8, 2012 | The Hunger Games | $20,772,462 | |
| 15 | April 15, 2012 | The Hunger Games | $19,505,216 | The Hunger Games matched Avatar's record of holding the top spot for 4 consecutive weeks. |
| 16 | April 22, 2012 | The Lucky One | $21,634,795 | |
| 17 | April 29, 2012 | The Pirates! Band of Misfits | $16,893,708 |